Royal Air Force Typhoon jets have conducted a mission with France's air force in a joint strike on an subterranean weapons facility in Syria operated by the IS group, as stated by the UK's MoD.
The location, identified by surveillance, was thought to be containing munitions and bombs, the announcement noted, and was located in mountains just north of Palmyra in Syria's central region.
"Our fighter planes used precision-guided Paveway IV munitions to strike a series of approach shafts leading to the site... preliminary assessments indicate the objective was successfully hit," officials stated.
There was no evidence of any harm to civilians in the strike on Saturday evening and every plane involved returned to base without incident, the ministry further stated.
The British jets were assisted by a Voyager tanker plane.
IS - also known as the so-called Islamic State - enforced extremist governance over large swathes of Syria and Iraq until 2019.
"This strike underscores the UK's leading role, and determination to operate in unison with our allies, to eradicate any resurgence of IS and their dangerous and violent ideologies in the area," the British Defence Secretary John Healey remarked.
British military aircraft have carried out patrols over Syria to "deter any attempted resurgence" of Islamic State after its defeat at the climactic battle in Baghuz in 2019, the authorities noted.
"I must thank every member of the UK armed forces who took part in this operation for their professionalism and their bravery," the Defence Secretary said. "They were among a great many UK service members deployed over Christmas and New Year. This mission, to take out militants who pose a risk to our way of life, highlights how our armed forces are prepared to act, all year round, keeping Britain secure within its borders and powerful internationally."
In December, the United States armed forces conducted what it called a "large-scale strike" against IS targets in the country, following an attack killed two American soldiers and a civilian linguist in the Palmyra area.
The United Nations reports Islamic State still maintains an estimated 5,000 to 7,000 militants in Syria and Iraq.